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Pacheco, A., Torres, R., Sanhueza, M
Mechanistically, E2F1-mediated CHAC1 upregulation promotes PKM2 SUMOylation enabling PKM2 nuclear translocation or kinase activation (Pan et al., 2024)
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These products are cleaved into glutamine, cysteine, and glycine under the action of 5-oxoalaninase and Cys-Gly peptidase, respectively, and then added to new GSH synthesis [32, 37] (summarized in Fig
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